Endocrine Abstracts

Leptin hormone is mainly secreted from adipose tissue and has an important role in energy metabolism. There have been very few studies examining effects of leptin on oxidant stress. The aim of the present study was to investigate whether leptin affects lipid peroxidation and antioxidant status in the brain of mice. Adult male Bulb-c mice were divided into two groups. Leptin was intraperitoneally administered to the first group at a dose of 40ug/animal for 5 days. Controls rece...

Introduction: The objective of this study was to investigate left atrial mechanical function (LAMF) and to associate these measurements with diastolic function in subclinical (SHT) and overt hypothyroidism (OHT).Methods: Twenty-six newly diagnosed patients with SHT (20F, 6M, mean age 42.2±12.5 years), 21 patients with OHT (17F, mean age 40.2±8.5 years) and 28 healthy volunteers (control group, 21F, 42.4±11.2 years) were enrolled in this st...

Seminal vesicles play important roles in male infertility due to their secretions and contractile properties. Beside their sympathetic and parasympathetic nerve supply, seminal vesicles are also innervated by purinergic stimuli. Additionally, prolactin affects the gonadal, seminal vesicle, prostate functions and contributes to seminal plasma and sexual function. Medical treatment of hyperprolactinemia usually involves dopamine agonists. In the present study, effects of treated...

Polychlorinated biphenyls (PCBs) are persistent environmental pollutants. Two industrial PCB mixtures, Aroclors 1221 and 1254 have been suggested to have estrogenic and anti-estrogenic properties, respectively. We have examined whether these PCB mixtures modulated bone formation and resorption in intact and ovariectomized (ovx) rat models. Twentyfour adult female rats were divided into three groups subcutaneously receiving 4% DMSO (Control), Aroclor 1221 (10 mg/kg) and Aroclor...

Brain catecholaminergic neurotransmitters are involved in the regulation of food intake. Increased dopamin and noradrenaline release in the lateral hypothalamic area (LHA) results in inhibition of food intake whereas stimulative effects have been reported in the medial nucleus. Elevated noradrenaline levels have been shown in the hypothalamus and nucleus accumbens (NAC) of hyperphagic-hypermetabolic rats. Effects of melatonin on food intake in various species have been controv...